Mohamed Salem started in 2007 performing at small gigs in Alexandria and Cairo. In June 2009 he performed at Sawy Culture wheel in the event "Egypt's funniest comedians", after that he hosted two shows "Agami Summer Nights" in August 2009. In December 2009 Mohamed performed in Jordan's "Amman Stand up Comedy Festival". In February 2010 he performed in the Moga stand up comedy show which can be seen on Moga comedy channel.